Featured publications
APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
November 6, 2023
Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V, Greicius MD. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA Neurol. 2023 Nov 6:e233599. doi: 10.1001/jamaneurol.2023.3599. Epub ahead of print. PMID: 37930705; PMCID: PMC10628838.
A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data
August 11, 2022
Belloy ME, Le Guen Y, Eger SJ, Napolioni V, Greicius MD, He Z. A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data. Neurol Genet. 2022 Aug 11;8(5):e200012. doi: 10.1212/NXG.0000000000200012. PMID: 35966919; PMCID: PMC9372872.
Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
May 31, 2022
Le Guen Y, Belloy ME, Grenier-Boley B, de Rojas I, Castillo-Morales A, Jansen I, Nicolas A, Bellenguez C, Dalmasso C, Küçükali F, Eger SJ, Rasmussen KL, Thomassen JQ, Deleuze JF, He Z, Napolioni V, Amouyel P, Jessen F, Kehoe PG, van Duijn C, Tsolaki M, Sánchez-Juan P, Sleegers K, Ingelsson M, Rossi G, Hiltunen M, Sims R, van der Flier WM, Ramirez A, Andreassen OA, Frikke-Schmidt R, Williams J, Ruiz A, Lambert JC, Greicius MD; Members of the EADB, GR@ACE, DEGESCO, DemGene, GERAD, and EADI Groups; Arosio B, Benussi L, Boland A, Borroni B, Caffarra P, Daian D, Daniele A, Debette S, Dufouil C, Düzel E, Galimberti D, Giedraitis V, Grimmer T, Graff C, Grünblatt E, Hanon O, Hausner L, Heilmann-Heimbach S, Holstege H, Hort J, Jürgen D, Kuulasmaa T, van der Lugt A, Masullo C, Mecocci P, Mehrabian S, de Mendonça A, Moebus S, Nacmias B, Nicolas G, Olaso R, Papenberg G, Parnetti L, Pasquier F, Peters O, Pijnenburg YAL, Popp J, Rainero I, Ramakers I, Riedel-Heller S, Scarmeas N, Scheltens P, Scherbaum N, Schneider A, Seripa D, Soininen H, Solfrizzi V, Spalletta G, Squassina A, van Swieten J, Tegos TJ, Tremolizzo L, Verhey F, Vyhnalek M, Wiltfang J, Boada M, García-González P, Puerta R, Real LM, Álvarez V, Bullido MJ, Clarimon J, García-Alberca JM, Mir P, Moreno F, Pastor P, Piñol-Ripoll G, Molina-Porcel L, Pérez-Tur J, Rodríguez-Rodríguez E, Royo JL, Sánchez-Valle R, Dichgans M, Rujescu D. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA Neurol. 2022 Jul 1;79(7):652-663. doi: 10.1001/jamaneurol.2022.1166. PMID: 35639372; PMCID: PMC9157381.
Recent publications
- APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathologyChemparathy, A., Le Guen, Y., Chen, S., Lee, E. G., Leong, L., Gorzynski, J. E., Jensen, T. D., Ferrasse, A., Xu, G., Xiang, H., Belloy, M. E., Kasireddy, N., Peña-Tauber, A., Williams, K., Stewart, I., Talozzi, L., Wingo, T. S., Lah, J. J., Jayadev, S., Hales, C. M., & 8 othersPeskind, E., Child, D. D., Roeber, S., Keene, C. D., Cong, L., Ashley, E. A., Yu, C. E. & Greicius, M. D., Apr 3 2024, In: Neuron. 112, 7, p. 1110-1116.e5Research output: Contribution to journal › Article […]
- APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population AncestryBelloy, M. E., Andrews, S. J., Le Guen, Y., Cuccaro, M., Farrer, L. A., Napolioni, V. & Greicius, M. D., Dec 11 2023, In: JAMA Neurology. 80, 12, p. 1284-1294 11 p.Research output: Contribution to journal › Article › peer-review
- APOE effects on regional tau in preclinical Alzheimer’s diseaseFor the Alzheimer’s Disease Neuroimaging Initiative, the A4 Study Team, Young, C. B., Johns, E., Kennedy, G., Belloy, M. E., Insel, P. S., Greicius, M. D., Sperling, R. A., Johnson, K. A., Poston, K. L. & Mormino, E. C., Dec 2023, In: Molecular neurodegeneration. 18, 1, 1.Research output: Contribution to journal › Article › peer-review
- APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathologyTalyansky, S., Le Guen, Y., Kasireddy, N., Belloy, M. E. & Greicius, M. D., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 149.Research output: Contribution to journal › Article › peer-review
- Improving genetic risk prediction across diverse population by disentangling ancestry representationsGyawali, P. K., Le Guen, Y., Liu, X., Belloy, M. E., Tang, H., Zou, J. & He, Z., Dec 2023, In: Communications Biology. 6, 1, 964.Research output: Contribution to journal › Article › peer-review
- Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene–gene interaction of longevity-related lociDato, S., De Rango, F., Crocco, P., Pallotti, S., Belloy, M. E., Le Guen, Y., Greicius, M. D., Passarino, G., Rose, G. & Napolioni, V., Sep 2023, In: Aging Cell. 22, 9, e13938.Research output: Contribution to journal › Article › peer-review
- Association of African Ancestry-Specific APOE Missense Variant R145C with Risk of Alzheimer DiseaseLe Guen, Y., Raulin, A. C., Logue, M. W., Sherva, R., Belloy, M. E., Eger, S. J., Chen, A., Kennedy, G., Kuchenbecker, L., O'Leary, J. P., Zhang, R., Merritt, V. C., Panizzon, M. S., Hauger, R. L., Gaziano, J. M., Bu, G., Thornton, T. A., Farrer, L. A., Napolioni, V., He, Z., & 1 othersGreicius, M. D., Feb 21 2023, In: JAMA. 329, 7, p. 551-560 10 p.Research output: Contribution to journal › Article › peer-review
- Post-translational modifications linked to preclinical Alzheimer's disease–related pathological and cognitive changesAbiose, O., Rutledge, J., Moran-Losada, P., Belloy, M. E., Wilson, E. N., He, Z., Trelle, A. N., Channappa, D., Romero, A., Park, J., Yutsis, M. V., Sha, S. J., Andreasson, K. I., Poston, K. L., Henderson, V. W., Wagner, A. D., Wyss-Coray, T. & Mormino, E. C., 2023, (Accepted/In press) In: Alzheimer's and Dementia. 20, 3, p. 1851-1867 17 p.Research output: Contribution to journal › Article › peer-review
- Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1∗04 subtypesEADB, GR at ACE study group, DEGESCO consortium, Demgene, EADI, GERAD & Asian Parkinson’s Disease, Genetics consortium, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 36, e2302720120.Research output: Contribution to journal › Article › peer-review
- GWAS of Genetic Resilience to Age-Related Risk for Alzheimer’s Disease in Admixed African Ancestry IndividualsBelloy, M. E., Guen, Y. L., Eger, S. J., Napolioni, V., He, Z., Mormino, E. C. & Greicius, M. D., Dec 2022, In: Alzheimer's and Dementia. 18, S4, e065315.Research output: Contribution to journal › Comment/debate