Featured publications
Role of X Chromosome in Alzheimer’s Disease Genetics
September 9, 2024
Belloy ME, Le Guen Y, Stewart I, Williams K, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue M, Napolioni V, Greicius MD. Role of the X Chromosome in Alzheimer Disease Genetics. JAMA Neurol. 2024 Sep 9:e242843. doi: 10.1001/jamaneurol.2024.2843. Epub ahead of print. PMID: 39250132; PMCID: PMC11385320.
APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
November 6, 2023
Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V, Greicius MD. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA Neurol. 2023 Dec 1;80(12):1284-1294. doi: 10.1001/jamaneurol.2023.3599. PMID: 37930705; PMCID: PMC10628838.
A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data
August 11, 2022
Belloy ME, Le Guen Y, Eger SJ, Napolioni V, Greicius MD, He Z. A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data. Neurol Genet. 2022 Aug 11;8(5):e200012. doi: 10.1212/NXG.0000000000200012. PMID: 35966919; PMCID: PMC9372872.
Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
May 31, 2022
Le Guen Y, Belloy ME, Grenier-Boley B, de Rojas I, Castillo-Morales A, Jansen I, Nicolas A, Bellenguez C, Dalmasso C, Küçükali F, Eger SJ, Rasmussen KL, Thomassen JQ, Deleuze JF, He Z, Napolioni V, Amouyel P, Jessen F, Kehoe PG, van Duijn C, Tsolaki M, Sánchez-Juan P, Sleegers K, Ingelsson M, Rossi G, Hiltunen M, Sims R, van der Flier WM, Ramirez A, Andreassen OA, Frikke-Schmidt R, Williams J, Ruiz A, Lambert JC, Greicius MD; Members of the EADB, GR@ACE, DEGESCO, DemGene, GERAD, and EADI Groups; Arosio B, Benussi L, Boland A, Borroni B, Caffarra P, Daian D, Daniele A, Debette S, Dufouil C, Düzel E, Galimberti D, Giedraitis V, Grimmer T, Graff C, Grünblatt E, Hanon O, Hausner L, Heilmann-Heimbach S, Holstege H, Hort J, Jürgen D, Kuulasmaa T, van der Lugt A, Masullo C, Mecocci P, Mehrabian S, de Mendonça A, Moebus S, Nacmias B, Nicolas G, Olaso R, Papenberg G, Parnetti L, Pasquier F, Peters O, Pijnenburg YAL, Popp J, Rainero I, Ramakers I, Riedel-Heller S, Scarmeas N, Scheltens P, Scherbaum N, Schneider A, Seripa D, Soininen H, Solfrizzi V, Spalletta G, Squassina A, van Swieten J, Tegos TJ, Tremolizzo L, Verhey F, Vyhnalek M, Wiltfang J, Boada M, García-González P, Puerta R, Real LM, Álvarez V, Bullido MJ, Clarimon J, García-Alberca JM, Mir P, Moreno F, Pastor P, Piñol-Ripoll G, Molina-Porcel L, Pérez-Tur J, Rodríguez-Rodríguez E, Royo JL, Sánchez-Valle R, Dichgans M, Rujescu D. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. JAMA Neurol. 2022 Jul 1;79(7):652-663. doi: 10.1001/jamaneurol.2022.1166. PMID: 35639372; PMCID: PMC9157381.
Recent publications
- Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit allfor the Alzheimer's Disease Neuroimaging Initiative, Dec 2024, In: Alzheimer's and Dementia. 20, 12, p. 8595-8604 10 p.Research output: Contribution to journal › Article › peer-review
- Role of the X Chromosome in Alzheimer Disease GeneticsBelloy, M. E., Le Guen, Y., Stewart, I., Williams, K., Herz, J., Sherva, R., Zhang, R., Merritt, V., Panizzon, M. S., Hauger, R. L., Gaziano, J. M., Logue, M., Napolioni, V. & Greicius, M. D., Oct 14 2024, In: JAMA Neurology. 81, 10, p. 1032-1042 11 p.Research output: Contribution to journal › Article › peer-review
- Hippocampal volumes in UK Biobank are associated with APOE only in older adultsChaloemtoem, A., Thornton, V., Chang, Y., Anokhin, A. P., Belloy, M. E., Bijsterbosch, J., Gordon, B. A., Hartz, S. M. & Bierut, L. J., Oct 1 2024, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 16, 4, e70024.Research output: Contribution to journal › Article › peer-review
- Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conferenceKloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba-Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., Gate, D., Golden, L. R., Heinecke, J. W., Herz, J., Huang, Y., Iadecola, C., Johnson, L. A., Kanekiyo, T., Karch, C. M. & Khvorova, A. & 40 others, Koppes-den Hertog, S. J., Lamb, B. T., Lawler, P. E., Guen, Y. L., Litvinchuk, A., Liu, C. C., Mahinrad, S., Marcora, E., Marino, C., Michaelson, D. M., Miller, J. J., Morganti, J. […]
- Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer’s diseaseBhattarai, P., Gunasekaran, T. I., Belloy, M. E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E. M., Hupalo, D. N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P. & Nuriel, T. & 10 others, Ertekin-Taner, N., Teich, A. F., Dickson, D. W., Holley, S., Greicius, M., Dalgard, C. L., Zody, M., Mayeux, R., Kizil, C. & Vardarajan, B. N., Jun 2024, In: Acta Neuropathologica. 147, 1, 70.Research output: Contribution to journal › Article […]
- APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathologyChemparathy, A., Le Guen, Y., Chen, S., Lee, E. G., Leong, L., Gorzynski, J. E., Jensen, T. D., Ferrasse, A., Xu, G., Xiang, H., Belloy, M. E., Kasireddy, N., Peña-Tauber, A., Williams, K., Stewart, I., Talozzi, L., Wingo, T. S., Lah, J. J., Jayadev, S. & Hales, C. M. & 8 others, Peskind, E., Child, D. D., Roeber, S., Keene, C. D., Cong, L., Ashley, E. A., Yu, C. E. & Greicius, M. D., Apr 3 2024, In: Neuron. 112, 7, p. 1110-1116.e5Research output: Contribution to journal […]
- A 39UTR Insertion Is a Candidate Causal Variant at the TMEM106B Locus Associated With Increased Risk for FTLD-TDPChemparathy, A., Le Guen, Y., Zeng, Y., Gorzynski, J., Jensen, T. D., Yang, C., Kasireddy, N., Talozzi, L., Belloy, M., Stewart, I., Gitler, A. D., Wagner, A. D., Mormino, E., Henderson, V. W., Wyss-Coray, T., Ashley, E., Cruchaga, C. & Greicius, M. D., Feb 5 2024, In: Neurology: Genetics. 10, 1, e200124.Research output: Contribution to journal › Article › peer-review
- APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population AncestryBelloy, M. E., Andrews, S. J., Le Guen, Y., Cuccaro, M., Farrer, L. A., Napolioni, V. & Greicius, M. D., Dec 11 2023, In: JAMA Neurology. 80, 12, p. 1284-1294 11 p.Research output: Contribution to journal › Article › peer-review
- APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathologyTalyansky, S., Le Guen, Y., Kasireddy, N., Belloy, M. E. & Greicius, M. D., Dec 2023, In: Acta Neuropathologica Communications. 11, 1, 149.Research output: Contribution to journal › Article › peer-review
- Improving genetic risk prediction across diverse population by disentangling ancestry representationsGyawali, P. K., Le Guen, Y., Liu, X., Belloy, M. E., Tang, H., Zou, J. & He, Z., Dec 2023, In: Communications Biology. 6, 1, 964.Research output: Contribution to journal › Article › peer-review